24 Mar 2025

Scientists claim to destroy breast cancer genes with antibodies



No complicated surgery. No painful chemotherapy or radiotherapy. A type of antibody capable of destroying cancer cells. Researchers are trying to cure breast and cervical cancer with immunotherapy. 

Scientists at King's College London are researching a new type of antibody therapy. Researcher Heather Bax said that until now, attempts have been made to cure any disease with immunoglobulin G (IgG) antibodies. But there is another type of antibody called immunoglobulin E (IgE) that can build an immune system against cancer cells. The researchers confirmed this by testing it on mice.

Scientists say that the most common type of breast cancer is ER/PR (estrogen and progesterone) positive and HER2 negative. Two genes, HER1 and HER2, are responsible for breast cancer. Of these, HER2 is the gene that increases the risk of cancer coming back even after it has been cured. Scientists have started researching how to overcome this gene. 

Research shows that if immunoglobulin E (IgE) antibodies can be introduced into a patient's body, they will directly attack the cancer gene. They will also activate the rest of the body's immune cells in such a way that the gene can no longer cause cancer.

 Breast cancer can be cured in many cases if caught early. Just as breast cancer can be cured if caught early, it can also come back five to seven years after it has been cured. In medical terms, this is called 'metastatic development'. 

Scientists say that cancer is usually unlikely to return for the first five years after treatment, but if the HER2 gene is active, there is a risk of the disease returning. In that case, scientists also claim that treatment with antibodies can eliminate the cancer cells from the beginning.

Another researcher at King's College London, Sophia Karagiannis, said that this particular antibody is being used not only in the treatment of breast cancer, but also in the treatment of various other types of cancer. Scientists have also seen that this antibody works very well in the human body. If all goes well, the scientists also said that this therapy will be applied to cancer patients around the world within the next 3 to 5 years.


 


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